DxNA has developed a mobile, rapid, easy-to-use point-of-care testing technology with real-time reporting capabilities. The breakthrough, patent-protected GeneSTAT instrumentation and chemistry allows individuals with almost no training to successfully conduct accurate and precise real-time PCR almost anywhere. PCR can now be performed in virtually any laboratory, clinic, or physician’s office, not only in developed regions in the United States, Europe and Japan but also in the primitive settings characteristic of rural and economically challenged regions.
The portability of the GeneSTAT technology allows on-site animal and plant disease testing -- on farms and ranches as well as in forests, deserts and or other remote locations. The ability to do analyses anywhere eliminates the need for sample/specimen preservation and transportation, and saves crucial days as to getting final results. Rapid, point-of-care testing has emerged as an ideal solution for faster detection of potentially pandemic diseases affecting humans, animals or crops.
The GeneSTAT Closed-System Test Module
The GeneSTAT Test Module is a disposable, pocket sized, single use plastic unit. It cannot be re-opened once a sample has been inserted, and literally all steps from initial sample processing -- during which DNA and RNA are solubilized and purified and PCR inhibitors removed or constrained -- to DNA amplification happen inside.
This unique, patent-protected closed-system design assures biohazard safety and prevents the carry-over of PCR products from one reaction to another that can confound results. In contrast, contamination from prior PCR reactions is an occasional problem with laboratory-based analytical systems. Importantly, a closed nature also means that DNA determinations can be done safely with dangerous pathogens that otherwise would have to be examined under special biosafety conditions.
Unique, Extraordinarily Sensitive Detection Optics
Patented optics exclusive to GeneSTAT, the DxNA Photometric Cell, are capable of exponentially better detection sensitivities than what might otherwise be achieved with the Charge-Coupled Devices (CCD; integrated circuitry that can convert fluorescent signals into electrical ones for detection) that typify most PCR machines, let alone PIN Diodes (semiconductor-based devices that detect light signals as an increase in electrical conductivity) and other technologies like fiber optics. Their lesser sensitivities are largely due to mechanical and electrical noise or to signal attenuation inherent to use. Meanwhile, DxNA Photometric Cells are so sensitive that these can detect a signal when very little target is present and the associated fluorescent signal low.
Cost is a key driver for successfully moving PCR testing from the laboratory to almost anywhere. Designed with economy in mind, the GeneSTAT System is inherently less costly than are the PCR devices typical of large clinical laboratories.